comsolmultiphysics is used for this study. We investigate the micropump performance at human skin interfacial pressure to match minimum to maximum delivery targets/requirements for total range of diabetic patient's expected operating parameters. In this study, we address various aspects of design and simulation of a MEMS-based piezoelectric insulin micropump including polydimethylsiloxane microvalves and microneedle array. Different input voltages and different excitation frequencies cause movement of piezoelectric actuator, which moves the diaphragm disk in positive-negative directions thereby inducing discharge pressures at the microneedle array. Crossref Google Scholar 62 Wu X, He L, Hou Y, Tian X and Zhao X 2021 Advances in passive check valve piezoelectric pumps Sens. The model captures the accumulated out-flow, the netflow, or flow fluctuations based on deflection of piezoelectric diaphragm actuator. 61 Spencer W J, Corbett W T, Dominguez L R and Shafer B D 1978 An electronically controlled piezoelectric insulin pump and valves IEEE Trans. We use a Multiphysics simulation system to investigate the performance of a MEMS-based insulin micropump with a piezoelectric actuator pumping a viscous Newtonian fluid. The design of positive volumetric insulin pump is a Multiphysics problem where the volumetric changes of the main pump chamber and the pumped fluid are directly coupled. The use of microneedle array provides a safe, painless, and robust injection application. The stackable structure provides minimum dimensions and the final product can be in the form of a patch that can be applied to any flat area of human skin. A 3D finite element model is built for the piezoelectric actuator. The properties for the piezoelectric disc (PZT-5A) and the elastic pump membrane (Si) are summarized in appendix. The piezoelectric actuator dimensions are listed in Table 1. Microneedle-based MEMS drug delivery devices can be an excellent solution for insulin dosing. We assume that the elastic pump membrane is entirely covered by the piezoelectric disc. Single needle mechanical insulin pumps are heavy and painful. One of the most effective treatments for type 1 and 2 diabetes is the administration of Insulin.
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